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BUSM scientists identify new biomarker and melanoma treatment target

February 13, 2016

In a clinical validation study, ColoVantage correctly identified colorectal cancer in 70 percent of samples of people diagnosed with the cancer. It also correctly detected the absence of colorectal cancer in about 89 percent of samples tested.

"ColoVantage cannot replace colonoscopy, and it has yet to be validated for colon cancer screening," said Jay G. Wohlgemuth, M.D., vice president, science and innovation, Quest Diagnostics. "But the test's ability to detect this cancer may persuade nonadherent screening-eligible individuals who receive a positive result to undergo colonoscopy or other evaluation."

Quest Diagnostics was the first laboratory in the United States to offer a molecular test employing blood taken from a patient's arm for aiding in the detection of colorectal cancer when it released ColoVantage in December 2009. New York is the only U.S. state with an independent regulatory review process for laboratory developed tests, which are also regulated at the federal level. With the approval, Quest Diagnostics can offer ColoVantage in New York as well as in all other U.S. states.

Colorectal cancer is the third most common cancer in men and women in the U.S., with more than 51,000 deaths expected this year, according to estimates from ACS.

SOURCE Quest Diagnostics Incorporated