Gene expression changes in prostate tissue surrounding cancer lesions may allow prostate cancer diagnosis

March 19, 2016

"If validated by others, this has potential significant clinical applications.  A patient with an equivocal biopsy or small acinar proliferation, or atypia, could potentially have the presence of cancer confirmed by a positive test on the nearby stroma, thereby saving the patient repeat biopsies," stated Dr. Kane.

Dr. Mercola further stated: "Important other potential uses are determining who needs expedited repeat biopsy and providing patients with new choices such as neo-adjuvant therapy and prevention therapy with drugs like finasteride. Finally the genes of our diagnostic profile are 'early detection biomarkers.'"

Additional validation studies will be required to confirm the findings, and before pathologists and urologists will likely be able to use a diagnosis based on non-tumor tissue for recommending surgery or other radical treatment, according to the researchers.

Proveri Inc. is developing biopsy tissue based diagnostic and prognostic clinical assays for improved prostate cancer management. The Company combines prostate cancer specific biomarkers detectable in tumor surrounding tissue via immunofluorescence, digital imaging and image analysis.

SOURCE Proveri Inc.