gesunheitpfleges.org



Genta initiates new Phase 2 clinical trial of tesetaxel in patients with advanced prostate cancer

December 12, 2015

They found that the microvesicles contained tumor DNA as well as RNA and that microvesicles from one of the pediatric tumors studied had elevated levels of both DNA and RNA from the oncogene c-Myc, which correlated with the gene's expression in that tumor. "We showed that amplification of c-Myc was present in microvesicles whenever it was present in the donor cell and that microvesicle analysis can reveal oncogene expression in the original tumor," explains Leonora Balaj of MGH Neurology, the first author of the study.

High levels of retrotransposon-associated RNA sequences were also detected in tumor microvesicles, and the investigators found those microvesicles could transfer their contents into normal cells. "One of the most important functions of tumor-derived microvesicles may be modification of normal cells in the microenvironment to make them more supportive of tumor growth," says study co-author Xandra Breakefield, PhD, MGH Neurology and a professor of Neurology at Harvard Medical School.

Source: Massachusetts General Hospital