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New findings suggest novel approach to targeted treatment of cancer

August 18, 2015

"The poles of the spindle are generated by a pair of structures called centrosomes, which are normally held in close proximity in cells, but which at the start of cell division move to opposite ends of the cell. Failure of centrosome separation blocks division of cells and can ultimately lead to cell death.

"Our research has identified new proteins that control centrosome separation as well as assessing the relative contributions of these together with previously described regulators. Importantly, this work suggests exciting new approaches to the targeted treatment of diseases characterized by deregulated cell division, such as cancer, as inhibitors of centrosome separation have the potential to prevent uncontrolled cell proliferation.

"Moreover, combining drugs against different regulators may reduce cytotoxic side-effects by allowing reduced concentrations of each inhibitor to be used in patients.

"In order to undertake proof of principle experiments, we are now in the process of developing inhibitors against these novel centrosome separation regulators in collaboration with the Institute of Cancer Research in London and the Northern Institute for Cancer Research at the University of Newcastle."

Source: University of Leicester