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PVT1 gene may help reduce diabetic nephropathy

April 03, 2016

PVT1, also known as plasmacytoma variant translocation 1, was previously identified by Dr. DiStefano's team as a candidate gene for End Stage Renal Disease (ESRD), or kidney failure. Too much PVT1 also has been associated with breast and ovarian cancers, in which it may help cause cells to multiply out of control and fail to go through the normal process of cellular death.

Through RNA interference, which helps control which genes are active and the degree of their activity, researchers reduced the expression of PVT1, which in turn reduced the protein levels of ECM components.

In a related finding, TGen scientists discovered that PVT1 affects the expression of other genes - FN1, COL4A1 and PAI-1 - in a manner that is at least partially independent of TFFB1, a gene associated with tissue fibrosis, or tissue damage.

"Delineation of the relationship between TGFB1 and PVT1 represents a critical component toward understanding the molecular mechanisms underlying the regulation of ECM in diabetic nephropathy," said Dr. Lucrecia Alvarez, the study's lead author and a TGen post-doctoral fellow.

Source: The Translational Genomics Research Institute