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Researchers discover protein that suppresses melanoma progression

October 11, 2015

"Very little is known about melanoma epigenetics or the histone-mediated epigenetic changes in cancer in general, so these findings are a major step forward in our research. As we move ahead, we would like to determine how to inhibit CDK8 function, thereby inhibiting the growth of melanoma, as well as identify additional epigenetic changes in melanoma progression." said Dr. Bernstein. "What these discoveries really highlight is the need for further studies into the epigenetic code of cancer."

Melanoma is the most serious form of skin cancer and accounts for about 75 percent of all skin cancer deaths. Though the most preventable cause of melanoma is exposure to the sun's UV rays, other factors include genetics and immune system deficiencies. When detected early, melanoma is highly curable. According to American Academy of Dermatology, the average five-year survival rate for individuals whose melanoma is detected and treated before it spreads to the lymph nodes is 98 percent.

Source: www.mountsinai.