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Researchers identify cell of origin for sarcoma

December 18, 2015

Suman Malempati, M.D., assistant professor of pediatrics (hematology/oncology) and director of the Oncology Developmental Therapeutics Program at OHSU Doernbecher Children's Hospital, is the lead on a national clinical trial of one such growth factor inhibitor. This is the Children's Oncology Group's first trial incorporating a molecularly targeted drug into a clinical trial for childhood muscle cancer and was funded by CureSearch for Children's Cancer, a nationwide network of hospitals, doctors and leading scientists that develop new treatments for childhood cancer.

This type of therapy tailored to a cancer's mutation was first pioneered at OHSU by Brian J. Druker, M.D., director of the OHSU Knight Cancer Institute and recipient of the 2009 Lasker~DeBakey Clinical Medical Research Award, commonly referred to as America's Nobel Prize. Druker and colleagues developed Gleevec, the first genetically targeted, non-chemotherapy pill for chronic myeloid leukemia (CML) that left healthy cells unharmed and converted this fatal cancer into a manageable chronic condition.

Source: Oregon Health & Science University