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Scientists discover killer protein that protects against development of cancer

January 09, 2016

Importantly, the Trinity team also discovered that members of the Bcl-2 gene family could override this process, switching off the self-eating process and leading to survival of cancerous cells. This suggests that drugs targeting Bcl-2 might reactivate the natural self-destruction pathway and help to shrink tumours. The fact that mutant Ras triggers self-destruction of cells carrying this gene also helps to explain why the emergence of fully cancerous cells is relatively rare when we consider that the average human makes hundreds of billions of cells over the course of their lifetime.

Commenting on the findings, Professor Martin stated: "This discovery is an important step forward in our understanding of how cells in the early stages of cancer hit the autodestruct button and suggests new ways in which we may be able to re-activate this process in cancers that do manage to establish. This breakthrough has led directly from investment in research made by the Irish state over the past 10 years through important initiatives such as the establishment of Science Foundation Ireland."

Source: Trinity College Dublin